P-glycoprotein相关论文
Arsenic trioxide inhibits p-glycoprotein expression in multidrug-resistant human leukemia cells that
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Antiepileptic drug-induced multidrug resistance P-glycoprotein overexpression in astrocytes cultured
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Overexpression of glucosylceramide synthase and its significance in the clinical outcome of non-smal
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目的探讨谷氨酰胺酶2(GLS2)对肝胆管癌细胞5-氟尿嘧啶(5-Fu)化疗敏感性的作用及其机制。方法TIMER数据库检索GLS2在泛癌中表达水平......
目的探讨银杏叶提取物(ginkgo biloba extracts，EGb761)对血管性痴呆(vascular dementia，VD)大鼠学习记忆的影响及海马神经元的保护......
目的 探讨多药耐药基因(MDR)1 C3435T基因多态性对胃溃疡患者抗幽门螺杆菌(Hp)治疗的影响.方法 共采集Hp阳性的胃溃疡患者106例,按......
目的 研究慢性氟中毒大鼠大脑皮质中p-糖蛋白(P-glycoprotein,P-gp)和细胞核因子κB(Nuclear factor κB,NF-κB)的表达变化,探讨......
目的 探讨聚集素(CLU)在原发性肝细胞癌(HCC)中的表达及其与P-糖蛋白(P-gp)表达的相关性.方法 采用免疫组化法检测凋亡抑制基因CLU......
目的分析血清肿瘤标记物及Ki-67、P-糖蛋白（PGP）联合检测在结直肠癌淋巴转移及术后复发评估中的作用。方法回顾性分析接受手术治疗的......
目的肿瘤多药耐药性(Multi-drug resistance,MDR)的产生是阻碍癌症治疗的重要原因。多项研究发现,P-glycoprotein(P-gp)高表达是导......
目的 比较短发夹RNA干扰质粒与粉防已碱对结肠癌LoVo/5-氟尿嘧啶(5-FU)耐药细胞多药耐药性(MDR)的逆转作用.方法 用粉防己碱和靶向......
多药物抵抗是药物治疗难治性癫(癎)的主要障碍.有研究表明,多药物转运子P糖蛋白的表达增加和活性增强,阻止抗癫(癎)药物进入大脑是......
Effects of arsenic trioxide on drug transporting molecules in multidrug resistance malignant neoplas
Objective: To study the effect of arsenic trioxide (As2O3) on the expression of drug transporting molecules in multidrug......
HM30181A, a potent P-glycoprotein inhibitor, potentiates the absorption and in vivo antitumor effica
Objective:Delivery of chemotherapeutic drugs to the brain has remained a major obstacle in the treatment of glioma, owin......
目的探讨P-糖蛋白(P-glyeoprotein，P-gp)单克隆抗体(UIC2)在改善MRL/lpr狼疮鼠肾脏病变中的作用。方法24只14周龄雌性MRl/lpr狼疮鼠......
Potential synergic mechanism of Wutou-Gancao herb-pair by inhibiting efflux transporter P-glycoprote
Wutou-Gancao herb-pair is extensively used to attenuate the toxicity and enhance the efficacy of aconite. In this study,......
目的 探讨注射用丹参总酚酸(冻干)(SLI)对人CYP450酶和P-糖蛋白体外抑制作用以及对大鼠CYP1A2和CYP3A体内诱导作用.方法 ①应用P45......
目的评价P-糖蛋白及有机阳离子转运体对左氧氟沙星跨胃黏膜转运的影响。方法用大鼠胃黏膜与Ussing chamber技术建立胃黏膜体外模型......
目的研究左氧氟沙星在胃黏膜体外模型中的跨膜转运特征。方法用大鼠胃黏膜与尤斯灌流室建立胃黏膜体外模型,研究左氧氟沙星跨胃黏......
目的研究9种黄酮类化合物和5种芪类化合物对血脑屏障上P-糖蛋白(P-gp)外排沙奎那韦的影响。方法以过表达P-gp的马丁达比犬肾上皮细......
目的研究荷叶的乙醇提取物(LLE)、总黄酮部位(TF)和总生物碱部位(TA)对P-糖蛋白(P-gp)功能的影响。方法用Caco-2细胞模型,将实验分......
随着对口服抗糖尿病药物研究的不断深入,目前已证实格列苯脲能够安全有效地治疗妊娠期糖尿病。格列苯脲具有较低的胎盘透过率,对其......
目的 探索中国汉族重性抑郁障碍(MDD)患者多药耐药基因(MDR1)多态性与帕罗西汀疗效及药物不良反应的关联.方法 对116例MDD患者给予......
目的研究Bcap37及Bcap37/MDR1荷瘤裸鼠在依克立达(GF120918)干预前后的18F-FDG摄取变化，在活体内评价P-gp对18F-FDG摄取的影响。方......
目的建立大鼠肝外胆道闭锁模型，观察其99Tcm-MIBI肝胆动态显像变化特点及与P-糖蛋白表达的相关性。方法取SD大鼠12只，按随机数字表法......
目的 探讨环氧合酶(COX)-2在肝细胞癌发生、发展中的作用及其对P-糖蛋白(P-gp)表达的影响. 方法 收集2003年10月-2005年6月因肝癌......
Arsenic trioxide inhibits p-glycoprotein expression in multidrug-resistant human leukemia cells that
Objective To investigate the effects of arsenic trioxide (As2O3) on the apoptosis and p-glycoprotein (P-gp) expression ......
Antiepileptic drug-induced multidrug resistance P-glycoprotein overexpression in astrocytes cultured
Background Intractable epilepsy may be due to multidrug resistance induced by conventional antiepileptic drugs. The phe......
Background Multidrug resistance is associated with a poor prognosis in various human cancers. However, the clinical sig......
Comparison of antileukemic immunity mediated by dendritic cells derived from multidrug resistant leu
Dendritic cells (DCs), as the most potent antigen presenting cells in vivo, are central to generating specific immune r......
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Induction of actin disruption and downregulation of P-glycoprotein expression by solamargine in mult
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Background P-glycoprotein (P-gp) encoded by ATP-binding cassette sub-family B member 1 (ABCB1) gene is a kind of ATP-dep......
Identification of the Interaction between P-Glycoprotein and Anxa2 in Multidrug-resistant Human Brea
Objective To explore the interaction of Anxa2 with P-Glycoprotein(P-gp) in the migration and invasion of the multidrug-r......
HY152-J(1)是一个体外具有抗耐药结核活性的候选化合物。本试验建立了Caco-2细胞单层模型,采用LCMS/MS法考察了1与转运蛋白P-gp的......
Effects of arsenic trioxide on drug transporting molecules in multidrug resistance malignant neoplas
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
目的 测定儿童难治性癫(癎)及初诊癫(癎)患儿外周血白细胞多药耐药基因产物P糖蛋白(P-gp),建立儿童难治性癫(癎)耐药性客观指标及......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Overexpression of P-glycoprotein induces acquired resistance to imatinib in chronic myelogenous leuk
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
ZM-66, a New Podophyllotoxin Derivative Inhibits Proliferation and Induces Apoptosis in K562/ADM Cel
Objective To investigate the anti-tumor effect of ZM-66 on multidrug-resistant leukemic cell line K562/ADM. Methods The ......
为探究吕家坨井田地质构造格局,根据钻孔勘探资料,采用分形理论和趋势面分析方法,研究了井田7......
Objective: to study the clinical significance of Pglycoprotein (P-gp) in breast cancer. Methods: Expression of P-gp in 6......
多药耐药基因1(MDR1)产物P糖蛋白在药物的吸收、分布、代谢和分泌以及药物间的相互作用方面起了很大作用.耐药的程度取决于化疗所......
P-糖蛋白(P-gp)是最重要的肿瘤多药耐药蛋白之一;CD44分子异常表达与肿瘤的侵袭和转移密切相关.近年来的研究发现,P-gp和CD44分子......
